Viral Replication and Progression of Cancer

AIM & SCOPE It has been widely established that several virus infections are strictly correlated to the cancerogenesis and may induce, through their reactivation, severe damages during chemotherapy treatments. For example, the direct role that Hepatitis B virus (HBV) plays in the development of liver cancer is well known. Nevertheless, in other cases, as Hepatitis C virus (HCV) or Hepatitis Delta Virus (HDV) the direct role of viral replication in cancer progression is still controversial, especially in some areas, like Italy, where these infections are endemic. Aim of this project is to up date the epidemiological status of the incidence of HCC in Europe and HCV and HDV infection , with special attention to the changes during the time of route of transmission, and also investigate the interaction between viral reactivations and tumors.